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by Furusawa, Y. et al.Department of Radiological Sciences, Life Science Research Center, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan An ATM inhibitor showed...

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by Gagou, M.E. et al.Institute for Cancer Studies, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United KingdomBrdU incorporation only occurs in a minority of...

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by Smith, J. et al.Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UKThe ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.Adv. Cancer Res. 2010; 73-112[See paper]

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by Despras, E. et al.Centre Nationale de Recherche Scientifique (CNRS) UMR8200, Laboratoire Stabilité Génétique et Oncogenèse, Université Paris-Sud, Institut Gustave Roussy, FranceAddition of a low...

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by Zhang, Y.W. et al.Department of Pharmacology, Case Comprehensive Caner Center, School of Medicine, Case Western Reserve University, USAFurther, we show that low levels of Fbx6 and consequent...

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by Demidova, A.R. et al.Text changed: In cells deficient in both Chk1 and p53, Cdc25A down-regulation upon camptothecin-induced DNA damage is completely abolished, leading to severe defects in cell...

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by Enomoto, M. et al.Division of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, JapanNovel positive feedback loop between Cdk1 and Chk1 in the nucleus during G2/M...

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by Myers, K. et al.Institute for Cancer Studies, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United KingdomATR and Chk1 suppress a caspase-3-dependent apoptotic...

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by Leung-Pineda, V. et al.Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri, USAThis study shows that Chk1 abundance is regulated by the...

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by Xiao, Z. et al.Cancer Research, Abbott Laboratories, Abbott Park, IL 60064-6101, USAOf additional interest, we observed that the various colon cancer cell lines in general appear to express higher...

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by Yang, X.H. et al.Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USAChk1 and Claspin potentiate PCNA ubiquitination.Genes Dev. 2008;...

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by Matsuura, K. et al.Text changed: These results suggest that Chk1 is activated by caspase-mediated cleavage during apoptosis and might be implicated in enhancing apoptotic reactions rather than...

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by Rodriguez, R. et al.Institute for Cancer Studies, University of Sheffield, School of Medicine and Biomedical Sciences, Sheffield S10 2RX, UKApoptosis induced by replication inhibitors in...

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by Zhang, W.H. et al.Department of Pharmacology and Toxicology, and the Norris Cotton Cancer Center, Dartmouth Medical School, New Hampshire 03756, USAWe were unable to substantiate the recent...

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by Guervilly, J.H. et al.Equipe voie FANC/BRCA et Cancer, CNRS FRE2939, CEA LRC43V, Univ Paris-Sud, FranceThis work describes a complex crosstalk between CHK1 and the FANC/BRCA pathway: CHK1 activates...

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by Scorah, J. et al.Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USAA conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1...

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by Ikegami, Y. et al.Division of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, JapanChk1 phosphorylation at Ser286 and Ser301 occurs with both stalled DNA replication...

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by Bennett, L.N. et al.Biomedical Research Centre, Level 5, College of Medicine Dentistry and Nursing, University of Dundee, UKClaspin is phosphorylated in the Chk1-binding domain by a kinase distinct...

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by Gali-Muhtasib, H. et al.Department of Biology, American University of Beirut, Beirut, LebanonIn p53-/- cells, transfection with p53-wt vector and CHEK1 small interfering RNA treatment decreased...

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by Felts, S.J. et al.Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905, USAFunctioning of the Hsp90 machine in chaperoning checkpoint kinase I...

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by Vitale, I. et al.INSERM, U848, Cancer and Immunity, Villejuif, FranceChk1 inhibition activated p53-regulated transcripts including Puma/BBC3 in tetraploid but not in diploid tumor cells.PLoS. ONE....

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by Kim, C.J. et al.Department of Pathology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Republic of KoreaThese results suggest that the Chk1 gene is a target of genomic...

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by Verlinden, L. et al.Text changed: Further research is warranted to validate the use of Chk1 inhibitors in triple-negative breast carcinomas for which treatment strategies are limited at present...

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by Kreutzer, J. et al.Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense, DenmarkThese results suggest that protein kinase CK2 is involved...

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